Medicare Enrolled
Dr. Manuel Santiago, MD
Hematology & Oncology · San Antonio, TX
Practice pattern: Mixed Practice
— Diverse clinical practice across multiple procedure types
Low-engagement
Very High
DATA COVERAGE
Data in 4 of 4 federal sources
Measures public federal data availability — not provider quality
Informational, not a quality rating.
This page presents federal public records about Dr. Santiago from CMS (NPPES, Open Payments, Medicare Provider Utilization, PECOS). It is not medical advice, an endorsement, or a judgment of clinical quality. Always consult the provider directly and a licensed clinician for medical decisions. Read methodology →
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What this data tells you about Dr. Santiago
Dr. Manuel Santiago is a hematology & oncology specialist in San Antonio, TX, with 20 years of NPI registration. Based on federal Medicare data, Dr. Santiago performed 44,847 Medicare services across 2,816 unique beneficiaries.
Between the years covered by Open Payments, Dr. Santiago received a total of $4,416 from 25 pharmaceutical and/or device companies across 66 individual payments. These payments are legal, publicly disclosed under the federal Sunshine Act, and common in hematology & oncology. Most payments are for meals and travel — low-value interactions common across virtually all practicing physicians. Patients may wish to discuss these relationships with their provider.
The Data Coverage level for Dr. Santiago is Very High — reflecting how much public federal data is available about this provider. This is not a quality rating. Patients are encouraged to use this data as one of several factors when choosing a healthcare provider.
✓ 20 years in practice
▲ Top 21% volume in TX
$4,416 industry payments
Medicare Practice Summary
Medicare Utilization ↗44,847
Medicare services
Top 21% in TX for hematology & oncology
2,816
Unique beneficiaries
$4
Avg. Medicare payment
Medicare patients only (65+ / disabled) · Not a quality rating · How to read this →
~2,242 Medicare services per year of practice
Top procedures by volume
Ranked by number of services performed for Medicare patients. Avg. submitted charge is what the provider billed; avg. Medicare payment is what CMS paid.
| Procedure | Volume | Avg. paid | Avg. submitted |
|---|---|---|---|
| Iron infusion (Feraheme) An injection of ferumoxytol used to treat iron deficiency anemia in patients not on dialysis. |
15,810 | $0 | $5 |
| Azacitidine chemotherapy injection An injection of the medication azacitidine, measured at 1 mg per unit. |
9,700 | $0 | $13 |
| Darbepoetin injection (Aranesp) for anemia An injection of darbepoetin alfa used for non-end-stage renal disease purposes. |
6,350 | $2 | $20 |
| Contrast dye for imaging (iodine-based) A contrast agent containing 300-399 mg/ml of iodine used to enhance imaging studies. It is administered per milliliter to improve the visibility of internal structures. |
4,762 | $0 | $3 |
| Bortezomib injection, 0.1 mg Administration of a 0.1 mg dose of bortezomib medication via injection. |
1,330 | $4 | $116 |
| Blood draw (venipuncture) Insertion of a needle into a vein to collect a blood sample. |
702 | $8 | $20 |
| Comprehensive metabolic blood panel A blood test that measures a group of chemicals, including glucose, electrolytes, and kidney and liver function markers. |
684 | $10 | $64 |
| Complete blood count (CBC) with differential An automated laboratory test that measures the levels of red blood cells, white blood cells, and platelets in the blood, including a breakdown of the different types of white blood cells. |
675 | $8 | $36 |
| Office visit, established patient (30-39 min) A follow-up office visit for an existing patient lasting between 30 and 39 minutes. The visit involves medical evaluation and management of the patient's condition. |
495 | $87 | $368 |
| Injection, granisetron hydrochloride, 100 mcg | 440 | $0 | $24 |
| Lactate dehydrogenase (LDH) level test A blood test that measures the amount of lactate dehydrogenase, an enzyme found in many body tissues. It helps assess tissue damage or disease. |
332 | $6 | $31 |
| Dexamethasone injection (steroid) An injection of dexamethasone sodium phosphate, a corticosteroid medication, administered in a dose of 1 milligram. |
316 | $0 | $1 |
| Immunoglobulin light chain measurement A blood test that measures the levels of immunoglobulin light chains, which are proteins produced by plasma cells. |
238 | $17 | $60 |
| Ferritin level test (iron stores) A blood test that measures the level of ferritin, a protein that stores iron in the body. |
222 | $13 | $60 |
| Iron level test | 221 | $6 | $27 |
| Iron binding capacity test A blood test that measures the amount of iron in the blood and the blood's ability to bind and transport iron. |
221 | $8 | $35 |
| Anti-nausea injection (Aloxi/palonosetron) | 190 | $1 | $114 |
| Immunoglobulin level test A blood test that measures the level of gammaglobulins, which are immune system proteins. |
174 | $9 | $56 |
| Office visit, established patient (20-29 min) An office visit for an existing patient lasting between 20 and 29 minutes. The visit involves medical evaluation and management of the patient's condition. |
162 | $63 | $250 |
| Intravenous chemotherapy infusion, 1 hour or less Administration of chemotherapy medication directly into a vein. The procedure takes one hour or less to complete. |
120 | $96 | $707 |
| Reticulated platelet measurement A blood test that measures the level of young, newly formed platelets in the body. |
108 | $35 | $143 |
| Additional sequential IV infusion, 1 hour or less This code represents an additional intravenous infusion administered sequentially to a primary infusion. It covers the administration time of one hour or less. |
104 | $21 | $157 |
| Non-hormonal chemotherapy injection This procedure involves administering non-hormonal anti-neoplastic chemotherapy medication via injection into the skin or muscle tissue. |
101 | $54 | $211 |
| Automated red blood cell count with calculations A blood test that automatically counts red blood cells and performs additional calculations to assess blood health. |
100 | $5 | $26 |
| Intravenous infusion, 1 hour or less Administration of medication or fluid directly into a vein for therapeutic, preventive, or diagnostic purposes. The procedure lasts one hour or less. |
94 | $47 | $313 |
| Zoledronic acid injection, 1 mg An injection of zoledronic acid administered at a dose of 1 mg. |
87 | $6 | $431 |
| Serum protein measurement A blood test that measures the total amount of protein in the serum. It helps evaluate overall health and nutritional status. |
85 | $9 | $75 |
| Hospital follow-up visit, moderate complexity Follow-up hospital visit for an existing patient involving moderate medical decision making. The visit requires at least 35 minutes of time spent on the date of service. |
79 | $60 | $247 |
| Prothrombin time test (blood clotting) A laboratory test that measures how long it takes for blood to clot. This procedure evaluates the body's coagulation process. |
74 | $4 | $30 |
| Hospital follow-up visit, high complexity Subsequent hospital inpatient or observation care for an existing patient involving high-level medical decision making, with at least 50 minutes total time on the date of the encounter. |
74 | $90 | $357 |
| Drug injection, under skin or into muscle A procedure involving the administration of a medication or substance via injection into the subcutaneous tissue or muscle. |
72 | $10 | $96 |
| Carcinoembryonic antigen (CEA) level test A blood test that measures the level of carcinoembryonic antigen (CEA) protein. This test is used to monitor certain types of cancer. |
65 | $19 | $99 |
| Serum immunofixation test A laboratory test that analyzes a blood serum sample to identify specific abnormal proteins. The procedure uses an immunologic technique to detect and characterize these proteins. |
64 | $10 | $87 |
| New patient office visit (45-59 min) An initial office visit for a new patient lasting between 45 and 59 minutes. This code covers the total time spent by the physician or qualified healthcare professional on the date of the encounter. |
61 | $109 | $565 |
| Beta-2 microglobulin level test A blood test that measures the level of beta-2 microglobulin, a protein produced by cells in the body. |
54 | $16 | $96 |
| Intravenous injection of additional new drug or substance Administration of an additional new medication or substance directly into a vein. |
49 | $12 | $108 |
| Additional hour of intravenous infusion This code represents each additional hour of intravenous infusion beyond the initial hour for therapy, prevention, or diagnosis. |
43 | $16 | $100 |
| Sed rate test (inflammation marker) This automated test measures how quickly red blood cells settle in a tube to detect inflammation in the body. |
37 | $3 | $36 |
| Manual white blood cell count A laboratory test that involves examining a sample under a microscope to manually count the number of white blood cells present. |
34 | $4 | $22 |
| Complete blood count (CBC), automated An automated laboratory test that measures the levels of red blood cells, white blood cells, and platelets in the blood. |
34 | $6 | $34 |
| Irrigation of implanted venous access device This procedure involves flushing an implanted venous access device to clear blockages or maintain patency. It ensures the device remains functional for delivering medications or fluids. |
30 | $16 | $114 |
| Diphenhydramine injection, up to 50 mg An injection of diphenhydramine hydrochloride, an antihistamine medication, administered in a dose of up to 50 milligrams. |
30 | $1 | $7 |
| CT scan of chest with contrast A computed tomography scan of the chest using a contrast dye to enhance the visibility of internal structures. |
28 | $49 | $821 |
| Coagulation function measurement, d-dimer; quantitative | 27 | $10 | $129 |
| CT scan of abdomen and pelvis with contrast A CT scan that uses dye to create detailed images of the abdomen and pelvis. This imaging test helps doctors examine internal organs and structures in these areas. |
25 | $170 | $1,067 |
| Vitamin B-12 level test A blood test that measures the amount of vitamin B-12 in your body. |
24 | $15 | $76 |
| CT scan of abdomen with contrast A CT scan of the abdomen using a contrast dye to create detailed images of internal organs and structures. |
23 | $127 | $793 |
| Immunologic analysis for detection of tumor antigen, quantitative; ca 15-3 | 22 | $20 | $128 |
| Office visit, established patient, complex (40-54 min) An office or outpatient visit for an existing patient lasting between 40 and 54 minutes. This level of service is determined by the total time spent on the date of the encounter. |
21 | $123 | $496 |
| Urinalysis with microscopic exam A urine test performed manually that includes examining the sample under a microscope to check for abnormalities. |
16 | $3 | $28 |
| Folic acid level test A blood test that measures the amount of folic acid in the serum. |
13 | $14 | $73 |
| Intravenous infusion of new drug or substance, 1 hour or less This procedure involves administering a new medication or substance directly into a vein through an existing access site. The infusion is completed within one hour or less. |
13 | $45 | $344 |
| Initial hospital admission, moderate complexity Initial hospital inpatient or observation care for a new patient involving moderate-level medical decision making, with at least 55 minutes total time on the date of the encounter. |
12 | $89 | $470 |
How to read this data: This reflects Medicare patients only (typically 65+). Payment amounts are what Medicare paid the provider, not your out-of-pocket cost. A higher procedure volume generally indicates more experience with that procedure.
36.1% high complexity
52.4% medium
11.5% routine
Industry Payment Transparency
Open Payments through 2024 ↗$4,416
Total received (2018-2024)
Avg $631/year across 7 years
Top 45% in TX for hematology & oncology
25
Companies
66
Individual payments
All payments are legal and publicly reported · Not evidence of wrongdoing · How to interpret →
Payment profile
Industry payments classified by relationship type. Not all payments are equal — research and consulting reflect different relationships than speaking programs or meals.
Meals & Travel
Food, beverages, travel, and lodging — typically low-value
$3,007 (68.1%)
Speaking / Promotional
Speaker programs, honoraria, and industry-sponsored educational events
$1,409 (31.9%)
Payment trend by year
Annual totals from pharmaceutical and medical device companies.
2024
$147
2023
$286
2022
$63
2021
$12
2020
$505
2019
$1,678
2018
$1,725
Payments by company (2024)
Consulting
Speaking
Meals & Travel
Research
Incyte Corporation
$1,206
E.R. Squibb & Sons, L.L.C.
$532
Takeda Pharmaceuticals U.S.A., Inc.
$342
Janssen Biotech, Inc.
$298
Genentech USA, Inc.
$261
Amgen Inc.
$209
AstraZeneca Pharmaceuticals LP
$169
Gilead Sciences, Inc.
$158
Bayer HealthCare Pharmaceuticals Inc.
$141
Seattle Genetics, Inc.
$137
Ipsen Biopharmaceuticals, Inc
$127
EMD Serono, Inc.
$126
Eisai Inc.
$122
Agios Pharmaceuticals, Inc.
$122
PFIZER INC.
$103
Janssen Pharmaceuticals, Inc
$89
TESARO, Inc.
$88
Novartis Pharmaceuticals Corporation
$37
Apellis Pharmaceuticals, Inc.
$30
Alexion Pharmaceuticals, Inc.
$30
Puma Biotechnology, Inc.
$21
Medtronic, Inc.
$19
Celgene Corporation
$19
Exelixis Inc.
$16
Pharmacyclics LLC, An AbbVie Company
$14
Top 3 companies account for 47.1% of total payments
Associated products mentioned in payments ›
ADCETRIS · Alecensa · Aliqopa · Avastin · Bavencio · CALQUENCE · DARZALEX · EMPLICITI · ERLEADA · Empaveli · Erleada · INTERSTIM · Imbruvica · JAKAFI · KISQALI · Lenvima · NERLYNX · NINLARO · ONUREG · OPDIVO · Onivyde · Pomalyst · REBLOZYL · Stivarga · TALZENNA · TECENTRIQ · TIBSOVO · Trodelvy · ULTOMIRIS · VOTRIENT · Vectibix · XALKORI · XARELTO · XGEVA · ZEJULA
Should you be concerned? Payments from pharmaceutical and device companies are legal and common — 57% of U.S. physicians receive at least one. They often reflect legitimate consulting, research, or education. What matters is whether a recommended drug or device appears in your doctor's payment records. If so, consider asking your doctor about it. How to interpret this data →
Most payments (68%) are for meals and travel — low-value interactions that are common across virtually all practicing physicians.
Equivalent to $10 per 100 Medicare services performed
Geographic Context
Hematology & oncology specialists within 10 mi
56
Per 100K population
2.7
County median income
$70,571
Nearest hospital
SAN ANTONIO BEHAVIORAL HEALTHCARE HOSPITAL
0.0 mi
0.0 mi
Data Sources
| Provider Registry | ✓ NPPES | Weekly updates |
| Medicare Enrollment | ✓ PECOS | Monthly updates |
| Practice Data | ✓ Medicare Util. | Annual (CY lag) |
| Industry Payments | ✓ Open Payments | CY 2024 |
| Disciplinary History | — Not public | N/A |
This provider has data in 4 of 4 available federal datasets, with a Data Coverage level of Very High. This measures how much public data is available about a provider — not how good they are. How we calculate this →
Summary
Dr. Santiago is a mixed practice specialist, with above-average Medicare volume (top 21% in TX), with low-engagement industry engagement, with 20 years of NPI registration.
This summary is auto-generated from federal data. It describes data availability and patterns — not clinical quality. Read our methodology →
Frequently Asked Questions
Is Dr. Santiago experienced with iron infusion (feraheme)?
Based on Medicare claims data, Dr. Santiago performed 15,810 iron infusion (feraheme) services. Research suggests that higher procedure volume is often associated with better outcomes, particularly for complex procedures. Note that Medicare data only captures patients aged 65 and older, so the total practice volume across all patients is likely higher.
Does Dr. Santiago receive payments from pharmaceutical companies?
Yes. Dr. Santiago received a total of $4,416 from 25 companies across 66 individual payments. These payments are legal, publicly disclosed under the federal Sunshine Act, and common among physicians — 57% of all U.S. physicians receive at least one industry payment. Patients may wish to ask their doctor about these relationships, especially if a recommended drug or device appears in the payment records.
How do Dr. Santiago's costs compare to other hematology & oncology specialists in San Antonio?
Dr. Santiago's average Medicare payment per service is $4. Note that these figures represent what Medicare pays, not your out-of-pocket cost, which depends on your specific insurance plan and deductible. Procedure-level data above shows both what was submitted and what Medicare paid for each service type.
What does Data Coverage mean?
Data Coverage (currently Very High for Dr. Santiago) measures how much public federal data is available about a provider. It is not a quality rating. A "Very High" or "High" level means the provider has data across multiple federal sources (NPPES, PECOS, Medicare Utilization, Open Payments), indicating a long track record of practice, Medicare participation, and industry disclosure. A "Low" or "Moderate" level may simply mean the provider is newer, does not see Medicare patients, or has not received any industry payments — none of which are inherently negative. Read our full methodology →
Is this data up to date?
Each data source has its own update cycle. Provider registry data (NPPES) is updated weekly. Medicare enrollment (PECOS) is updated monthly. Medicare practice data has a ~2 year lag — the most recent available is typically 2 years prior. Industry payment data (Open Payments) is published annually, usually in June, covering the prior calendar year. We display the data date prominently on each section so you always know how current it is. See our data freshness policy →
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About this page
All data on this page is sourced verbatim from public federal records published by the U.S. Centers for Medicare & Medicaid Services (CMS): NPPES ↗, Open Payments ↗, Medicare Provider Utilization ↗, and PECOS. Publication is mandated by the Physician Payments Sunshine Act (§6002 ACA, 42 U.S.C. §1320a-7h) and the Freedom of Information Act.
This page is not medical advice, an endorsement, a recommendation, or a quality rating. The Transparency Score measures data completeness — how much federal information exists for this provider — not clinical performance, patient outcomes, or quality of care. Always verify information directly with the provider and consult a licensed clinician before making medical decisions.
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